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Urolithin A is one of the few longevity-focused compounds with genuine human research behind it, and Mitopure is the standardised form that research was largely built on. We chose this product because it pairs that specific ingredient with a liposomal delivery system, addressing one of the practical limitations of oral urolithin A supplementation. For patients interested in mitochondrial health, this is a more substantiated starting point than most options in this space.
About this product
Codeage Liposomal Urolithin A
A liposomal longevity formula delivering 500 mg of urolithin A alongside trans-resveratrol, betaine, and CoQ10 — the mitochondrial renewal compound that triggers your cells to recycle damaged energy factories and build new ones, addressing the root mechanism of cellular ageing that no antioxidant, vitamin, or lifestyle intervention can replicate.
Your cells are powered by mitochondria — thousands of tiny organelles that convert food into ATP, the energy currency every biological process depends on. When you are young, your body efficiently identifies and recycles damaged mitochondria through a process called mitophagy, replacing them with functional new ones. As you age, mitophagy slows. Damaged mitochondria accumulate. They produce less ATP and more reactive oxygen species — the metabolic waste that damages DNA, proteins, and cellular membranes from the inside out. The cascade is felt everywhere: declining energy, slower recovery, reduced muscle strength, impaired cognitive function, and the gradual erosion of cellular resilience that we experience as ageing. By your forties and fifties, you are running your body on an increasingly degraded energy infrastructure, and no amount of sleep, nutrition, or exercise can fully compensate for mitochondria that your body has stopped replacing.
The longevity supplement market has chased this problem with antioxidants for decades — vitamin C, vitamin E, CoQ10, resveratrol — each positioned as a defence against oxidative damage. And they help. But antioxidants neutralise the downstream consequences of mitochondrial dysfunction without addressing the upstream cause: the failure to remove damaged mitochondria and replace them with healthy ones. You mop the floor while the pipe keeps leaking. The fundamental problem — impaired mitophagy — remains, and the cellular energy deficit widens with every year. Until recently, the only known activator of mitophagy was caloric restriction and intense exercise. Neither is practical as a daily longevity intervention for most people.
Urolithin A changed the equation. It is a postbiotic — a compound produced when gut bacteria metabolise ellagitannins found in pomegranates, walnuts, and berries. But here is the problem: only an estimated 30 to 40% of the population has the specific gut bacteria required to produce urolithin A naturally. The rest consume pomegranates and receive negligible urolithin A regardless of how much they eat. Direct supplementation bypasses the gut microbiome bottleneck entirely. Urolithin A activates mitophagy at the cellular level — signalling your body to identify, disassemble, and recycle dysfunctional mitochondria, then stimulate the biogenesis of new, efficient replacements.
Published human clinical trials have demonstrated that urolithin A supplementation improves mitochondrial biomarkers, enhances muscle endurance, and reduces systemic inflammation. It is the first compound to directly target the mitochondrial quality control mechanism that declines with age. Codeage delivers 500 mg of urolithin A per two-capsule serving in a liposomal matrix using non-GMO sunflower-derived phosphatidylcholine — protecting the compound through digestion for enhanced bioavailability. The formula adds trans-resveratrol (98% purity from Japanese knotweed) for sirtuin activation and additional antioxidant support, CoQ10 for mitochondrial electron transport chain function, and betaine anhydrous for methylation and cellular hydration.
Vegan capsule. Non-GMO, gluten-free, soy-free, dairy-free, keto-friendly. 60 capsules per bottle — a one-month supply.
People who understand that ageing is fundamentally a mitochondrial quality control problem choose the compound that directly activates the recycling process your body has been neglecting. It signals a longevity approach that addresses the mechanism, not just the symptoms — clearing out the damaged energy factories rather than simply defending against the damage they produce.
What it does
Benefits
- 01
Supports mitochondrial clearance and renewal via mitophagy
- 02
Mitopure: the most clinically studied urolithin A form
- 03
May support muscle endurance and physical resilience with age
- 04
Liposomal format designed to optimise gut absorption
- 05
Useful for adults who cannot produce urolithin A naturally
Get the most from it
How to use
Take two capsules daily with 250 ml of water or your preferred beverage. Can be taken with or without food. Consistency is essential — mitochondrial turnover is a gradual process, and the benefits of mitophagy activation compound over weeks and months of uninterrupted supplementation. Most users report noticeable improvements in energy, recovery, and overall vitality within four to eight weeks. For maximum synergy, pair with regular exercise — physical activity independently stimulates mitophagy, and combining exercise with urolithin A supplementation may amplify the mitochondrial renewal response. Do not exceed the recommended dose. Not recommended for pregnant or breastfeeding women, or individuals under 18. Consult your healthcare professional if taking medications or managing a medical condition. Store in a cool, dry place. Keep out of reach of children. 60 capsules — one-month supply. The compound that tells your cells to stop tolerating broken mitochondria and start replacing them — because the energy crisis of ageing begins at the organelle level, and this is the first molecule proven to address it directly.
What's inside
Ingredients
View full ingredient list
Urolithin A 500 mg, Trans-Resveratrol (from Japanese Knotweed, Reynoutria japonica, standardised to 98%), Betaine Anhydrous (Trimethylglycine), Coenzyme Q10, Methylcellulose Capsule, Non-GMO Sunflower Oil (containing Phosphatidylcholine — Liposomal Delivery Matrix) Vegan. Non-GMO. Gluten-free. Soy-free. Dairy-free. Keto-friendly. No artificial colours, flavours, or preservatives.
Common questions
Frequently asked
What is Urolithin A and why can't I just get it from food?
Urolithin A is not found directly in food. It is produced by gut bacteria when they break down ellagitannins from foods like pomegranates and walnuts. Research suggests that a significant proportion of adults lack the specific gut bacteria needed to produce meaningful amounts, making direct supplementation the more reliable route.
What makes Mitopure different from generic Urolithin A?
Mitopure is a purified, standardised form of Urolithin A developed by Amazentis and is the most extensively studied version of the compound in human trials. Generic urolithin A ingredients vary widely in purity and have far less published evidence behind them.
How long before I notice any difference?
Mitophagy and mitochondrial renewal are slow biological processes. Most research protocols run for several weeks at minimum. It is reasonable to allow 8–12 weeks of consistent use before evaluating any change in energy or physical performance.
Is this suitable alongside other supplements or medications?
Urolithin A is not known to interact with common supplements, but if you are on prescription medication — particularly immunosuppressants or drugs with narrow therapeutic windows — it is worth checking with your GP or pharmacist before starting.
Why liposomal delivery specifically?
Liposomal encapsulation wraps the active compound in a phospholipid layer that may improve passage through the gut lining compared to standard oral formats. This is a common approach used to improve the bioavailability of compounds that are otherwise variably absorbed.
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