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Why The Wellness recommends this

Curated, not stocked.

Omega-3 deficiency is common and rarely symptomatic until flagged on testing. We include Life Extension Super Omega because EPA and DHA have some of the most consistent evidence across cardiovascular and cognitive health, and because the brand applies rigorous quality standards to its formulations. For patients whose blood work shows low omega-3 index or raised triglycerides, a reliable fish oil is one of the first additions we discuss.

About this product

Life Extension Super Omega

A high-potency wild fish oil concentrate delivering 2000 mg per serving with 700 mg EPA and 500 mg DHA, enriched with olive polyphenols equivalent to four tablespoons of extra virgin olive oil and sesame lignans that protect the fatty acids from oxidation — the Mediterranean diet in a softgel, backed by 40+ years of nutritional science.

Omega-3 fatty acids are not optional. EPA and DHA are structural components of every cell membrane in your body, with the highest concentrations in your brain, retina, and heart. They regulate inflammation, support cardiovascular function, maintain cognitive performance, protect joint mobility, and influence mood through serotonin receptor sensitivity. Your body cannot produce them. Every milligram must come from diet or supplementation. Yet the average Western diet delivers a fraction of what clinical research suggests is optimal, creating a chronic omega-3 deficit that drives silent inflammation — the low-grade, systemic kind that underlies cardiovascular disease, cognitive decline, joint degeneration, and accelerated ageing. You cannot feel it happening, which is precisely why most people do nothing about it until the consequences become visible.

The fish oil market is flooded with products that look adequate on the front of the bottle and disappoint on the back. Many contain low concentrations of EPA and DHA relative to total fish oil volume, meaning you swallow large capsules filled mostly with other fats that deliver no omega-3 benefit. Cheap processing leaves residual heavy metals, PCBs, and oxidised lipids. Standard fish oil capsules contain no antioxidant protection, so the polyunsaturated fatty acids begin to oxidise from the moment the bottle is opened — and oxidised omega-3 does more harm than good. Most fish oils also ignore the mounting evidence that omega-3 works best in concert with the polyphenols and antioxidants found in traditional Mediterranean dietary patterns, not in isolation.

Life Extension Super Omega takes a fundamentally different approach. The Pure+ wild fish oil concentrate is sourced from anchovy, sardine, mackerel, and jack mackerel — small, short-lived fish with naturally low contaminant accumulation — and refined to deliver 700 mg EPA and 500 mg DHA per daily serving in a concentrated format that minimises capsule count without sacrificing dose. Polyphen-Oil olive extract provides the polyphenol content of over four tablespoons of extra virgin olive oil, including hydroxytyrosol — one of nature's most potent antioxidants and a key compound in cardiovascular research on the Mediterranean diet. Sesame seed lignan extract protects the unsaturated fatty acids from oxidation both in the capsule and in your body, extending the functional lifespan of every dose. The combination replicates the synergistic relationship between omega-3 and plant polyphenols that Mediterranean populations have benefited from for generations — not through diet alone, but through deliberate, research-driven formulation.

EPA and DHA contribute to the maintenance of normal blood pressure and normal blood triglyceride levels. Life Extension has been advancing preventative nutritional science for over 40 years. Soy-free, gluten-free, non-GMO. Available in 60 softgels (15-day supply) or 240 softgels (60-day supply).

2000 mg wild fish oil concentrate per daily serving 700 mg EPA and 500 mg DHA — high-potency clinical dosing Polyphen-Oil olive extract providing 19.5 mg polyphenols including hydroxytyrosol Sesame seed lignans protect fatty acids from oxidation in capsule and in body Pure+ sourced from anchovy, sardine, mackerel, and jack mackerel EPA and DHA contribute to normal blood pressure and triglyceride levels Mediterranean-inspired formulation combining omega-3 with plant polyphenols Soy-free, gluten-free, non-GMO — 40+ years of nutritional science

People who understand that omega-3 supplementation is only as effective as its concentration, purity, and antioxidant protection choose formulations that address all three rather than settling for volume without quality. It reflects an approach to cardiovascular and cognitive health that mirrors the dietary patterns with the strongest longevity evidence.

You gain cardiovascular protection, which removes the silent inflammatory burden driving arterial and lipid dysfunction and enables the maintenance of normal blood pressure and triglyceride levels through therapeutic-dose EPA and DHA.

You gain cognitive maintenance, which removes the progressive DHA depletion in neuronal membranes that contributes to age-related cognitive decline and enables sustained brain cell membrane fluidity and neurotransmitter function.

You gain anti-inflammatory balance, which removes the chronic omega-6 dominance of modern Western diets and enables a healthier inflammatory response across joints, skin, gut, and systemic tissue

You gain polyphenol synergy, which removes the isolation of omega-3 from the antioxidant context in which it works best and enables the Mediterranean-pattern combination of fish oil and olive polyphenols in every serving.

You gain oxidative stability, which removes the risk of consuming rancid, oxidised fish oil that causes more harm than benefit and enables sesame lignan protection that preserves fatty acid integrity from bottle to bloodstream

What it does

Benefits

  1. 01

    EPA (eicosapentaenoic acid) is the primary anti-inflammatory omega-3, directly competing with arachidonic acid for inflammatory enzyme pathways, reducing the production of pro-inflammatory prostaglandins and leukotrienes throughout the body

  2. 02

    DHA (docosahexaenoic acid) constitutes approximately 40% of polyunsaturated fat in the brain and 60% in the retina, maintaining neuronal membrane fluidity, supporting synaptic transmission, and protecting against age-related cognitive decline

  3. 03

    EPA and DHA contribute to the maintenance of normal blood pressure (at a combined daily intake of 3 g) and normal blood triglyceride levels (at a combined daily intake of 2 g)

  4. 04

    Hydroxytyrosol from olive extract is one of the most potent natural antioxidants, with established cardiovascular research showing protection against LDL oxidation — a critical step in atherosclerotic plaque formation

  5. 05

    Sesame lignans inhibit the oxidative degradation of polyunsaturated fatty acids both within the capsule and after ingestion, preserving the biological activity of EPA and DHA throughout their functional lifespan

  6. 06

    The combination of omega-3 and olive polyphenols replicates the synergistic dietary pattern that longitudinal research has consistently associated with lower cardiovascular mortality in Mediterranean populations

Get the most from it

How to use

Take two softgels twice daily with meals (four softgels total per day) for the full 2000 mg fish oil concentrate with 700 mg EPA and 500 mg DHA. Taking with food containing dietary fat improves absorption. Can be taken at breakfast and dinner or all four at a single meal. If you experience any fishy aftertaste, take with food or freeze softgels before use. If taking anticoagulant or antiplatelet medications, or if you have a bleeding disorder, consult your healthcare provider before use. Not recommended during the two weeks before scheduled surgery. Consult your healthcare professional if pregnant, breastfeeding, or undergoing treatment for a medical condition. Store in a cool, dry place. Keep out of reach of children. The omega-3 your cardiovascular system and brain were designed to run on, protected by the polyphenols that Mediterranean populations have relied on for generations — because fish oil without antioxidant context is only half the science.

What's inside

Ingredients

View full ingredient list

Pure+ Wild Fish Oil Concentrate (from Anchovy, Jack Mackerel, Mackerel, Sardine) providing 700 mg EPA and 500 mg DHA, Polyphen-Oil Olive Extract (Fruit and Leaf) providing 19.5 mg Polyphenols, 5.2 mg Hydroxytyrosol/Tyrosol, 4.4 mg Verbascoside/Oleuropein, Sesame Seed Lignan Extract, Capsule Shell (Gelatin), Glycerin, Purified Water, Beeswax, Anti-Caking Agent (Silicon Dioxide), Caramel Colour, Natural Flavour, Emulsifier (Sunflower Lecithin), Antioxidant (Mixed Tocopherols), Maltodextrin, Antioxidant (Rosemary Extract) Contains fish and sesame. Not suitable for vegetarians or vegans.

Common questions

Frequently asked

Who is most likely to benefit from taking this?

People who eat oily fish fewer than twice a week, those with elevated triglycerides on a lipid panel, and anyone looking to support long-term cardiovascular or cognitive health. It is also commonly used during periods of high cognitive or physical demand.

Can I take this alongside other supplements or medications?

Fish oil can have a mild blood-thinning effect and may interact with anticoagulant medications such as warfarin. If you are on any blood-thinning therapy or have a clotting disorder, speak to your doctor before starting. It is generally well-tolerated alongside most other supplements.

How long before I notice a difference?

Omega-3 supplementation typically takes several weeks to meaningfully shift blood levels. Benefits related to triglycerides or cognitive markers tend to be assessed over months rather than days — consistent daily use is more important than any single dose.

Is this suitable for vegetarians or vegans?

No. The softgels contain fish-derived oil and the capsule shell is likely gelatin-based. Those seeking a plant-based omega-3 source should look for an algae-derived DHA and EPA product instead.

How should I store fish oil softgels?

Store in a cool, dry place away from direct sunlight. Some people keep them in the fridge to slow oxidation and reduce any fishy aftertaste. Check the packaging for the manufacturer's specific storage guidance.

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