Free deliveryWhy The Wellness recommends this
Curated, not stocked.
Apigenin earned its place on our shelves because the science behind CD38 inhibition is genuinely interesting — and often overlooked by people investing in NAD+ precursors. Addressing the enzyme that drains NAD+ is the logical complement to supplementing NAD+ directly. Longevity Box keeps the formulation clean and honest: one active, clearly labelled. That transparency is what we expect from brands we recommend.
About this product
Longevity Box Apigenin
Apigenin is a naturally occurring flavonoid found in chamomile, parsley, and celery. This supplement delivers it in a concentrated daily capsule format. In research settings, apigenin is studied primarily for its role in NAD+ metabolism — it inhibits CD38, an enzyme that consumes NAD+ as we age, which has made it a focus of longevity-oriented nutrition protocols. Declining NAD+ levels are associated with reduced cellular energy production, impaired DNA repair, and accelerated biological ageing. By supporting NAD+ availability, apigenin may complement other longevity-focused supplements such as NMN or NR.
Beyond its role in cellular metabolism, apigenin is also studied for its interaction with GABA receptors, which may help support a calmer mental state and contribute to sleep quality. It has demonstrated anti-inflammatory properties in laboratory and animal studies, though large-scale human trials remain limited.
This supplement suits those already engaging seriously with longevity nutrition — particularly people taking NAD+ precursors who want to address the CD38 drain side of the equation. It also appeals to individuals looking for a botanically derived sleep-support option. The formulation is straightforward: a single active ingredient at a defined dose, with no unnecessary additions. That simplicity makes it easy to stack without concern about overlapping ingredients.
What it does
Benefits
- 01
May support NAD+ levels by inhibiting CD38 activity
- 02
Studied for anti-inflammatory effects via flavonoid pathways
- 03
May promote calmness and improve sleep quality
- 04
Complements NMN or NR in longevity-focused supplement stacks
- 05
Single-ingredient formula suited to precise, stackable protocols
Get the most from it
How to use
Take one capsule daily. Apigenin's mild interaction with GABA receptors means some people prefer to take it in the evening. Follow the dosage guidance on the packaging and take consistently for best results.
What's inside
Ingredients
View full ingredient list
Apigenin 50mg
Common questions
Frequently asked
How does apigenin relate to NAD+ supplements like NMN or NR?
NMN and NR are precursors that help the body produce more NAD+. CD38, an enzyme that increases with age, rapidly consumes NAD+ and can undermine that effort. Apigenin is studied for its ability to inhibit CD38, so the two approaches may work in a complementary way — though speak to a clinician before combining multiple longevity supplements.
Can I take this if I am on medication?
Apigenin is a flavonoid compound and may interact with certain medications, particularly those metabolised by the CYP450 liver enzyme pathway. If you are on any prescribed medicines, check with your GP or pharmacist before starting.
Will this help me sleep?
Apigenin is studied for its mild interaction with GABA-A receptors, which may support a calmer mental state and contribute to sleep onset. It is not a sedative, but some people find taking it in the evening fits well with their wind-down routine.
How long before I might notice a difference?
For sleep-related effects, some users notice a difference within the first week or two. Effects related to NAD+ metabolism and cellular longevity are longer-term and unlikely to be subjectively felt — they are better assessed through periodic blood biomarker testing.
Is this suitable for vegetarians or vegans?
The packaging will confirm the capsule shell material and any excipients. Check the label directly, as we cannot confirm this from the product listing alone.
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