Free deliveryWhy The Wellness recommends this
Curated, not stocked.
Phosphatidylserine earns its place here because the evidence for its role in cognitive support and cortisol modulation is more substantive than most in this category. Thorne's formulation provides a clean, well-characterised 100 mg dose that allows genuine flexibility. We recommend it specifically to patients flagging cognitive fatigue, age-related memory concerns, or stress-driven cortisol patterns identified through testing.
About this product
Phosphatidylserine
Thorne Phosphatidylserine is a phospholipid supplement providing 100 mg of phosphatidylserine per capsule, a compound that forms a core structural component of neuronal cell membranes. It plays a role in maintaining membrane fluidity and supporting the signalling pathways involved in cognition, memory, and the body's cortisol response to stress.
Phosphatidylserine is one of the more studied nootropic-adjacent nutrients. The research base centres on age-related cognitive decline, working memory, and attentional performance — making it most relevant for adults noticing early memory lapses, those in cognitively demanding roles, or people managing high chronic stress loads where cortisol dysregulation is a concern. It is also used by athletes interested in blunting the cortisol spike following intense training.
It fits naturally into a morning or pre-training routine, taken alongside a meal. Because it supports membrane integrity broadly, some users combine it with omega-3 fatty acids, though that is a general category observation rather than a specific formulation claim.
Thorne is a brand our clinicians return to consistently. Their manufacturing standards are well-regarded within the practitioner community, and they tend to use clean, well-characterised ingredient forms. Phosphatidylserine at 100 mg per capsule allows flexible dosing across different use cases, from a single daily capsule for general brain health maintenance to higher intakes during periods of elevated cognitive or physical demand.
What it does
Benefits
- 01
Supports memory and cognitive function in adults
- 02
May help moderate cortisol response to physical stress
- 03
Maintains neuronal cell membrane integrity
- 04
Suited to high-stress or cognitively demanding lifestyles
- 05
Flexible dosing for maintenance or intensive use
Get the most from it
How to use
Take 1 capsule one to three times daily, as directed on the packaging. Taking capsules with a meal is generally advisable for phospholipid supplements. Adjust the number of capsules to your specific use case — lower end for general maintenance, higher end during periods of elevated stress or training load.
What's inside
Ingredients
View full ingredient list
Phosphatidylserine 100mg
Common questions
Frequently asked
Who is most likely to benefit from phosphatidylserine?
Adults experiencing age-related memory changes, those in high-stress or cognitively demanding roles, and athletes looking to support recovery by moderating post-exercise cortisol are the most studied groups. It is not a general-population supplement — it suits a specific need.
How long before I notice a difference?
Cognitive and stress-related benefits from phosphatidylserine tend to be gradual. Most research protocols run over several weeks to months, so a short trial of a few days is unlikely to be informative. Consistent daily use over at least four to six weeks is a more realistic assessment window.
Is it safe to take alongside other supplements or medications?
Phosphatidylserine is generally well tolerated, but if you are taking anticoagulants or anticholinergic medications, speak to your GP or clinician before starting. As with any supplement, disclose it to your prescribing doctor as part of your full picture.
Can I take it on an empty stomach?
Taking it with food is preferable. Phospholipids are fat-soluble compounds and are generally better absorbed alongside a meal containing some dietary fat.
How does the 100 mg per capsule dosing work in practice?
The 100 mg capsule format mirrors the lower end of doses used in cognitive research, while the one-to-three capsules daily range allows you to match intake to your goals. Check the label and, if in doubt, start at the lower end and discuss adjustments with a clinician.
Doctor-guided care
Test before you supplement.
Bloods are the only way to know what your body actually needs. We'll tell you which of these supplements earn their place.
Book a panelFrom real customers
Reviews
No reviews yet
Be the first to share your experience.
Loading reviews…
