Longevity Box

Timeline Mitopure Urolithin A

£55.00

The pure, clinically studied urolithin A that Timeline pioneered, delivered in daily softgels.

  • Mitopure is the pure, clinically studied form of urolithin A developed by Amazentis and used in every peer reviewed human clinical trial on urolithin A supplementation
  • Urolithin A activates mitophagy, the selective autophagy of damaged mitochondria, triggering cellular recycling of dysfunctional energy producing organelles and stimulating biogenesis of new, efficient replacements
  • Published human clinical trials at this exact dose have demonstrated improved mitochondrial biomarkers, increased muscle strength and endurance, and measurable improvements in cellular ageing markers
  • Only an estimated 30 to 40% of the population possesses the specific gut microbiome composition required to convert dietary ellagitannins (from pomegranates, walnuts, berries) into urolithin A. Direct supplementation with Mitopure bypasses this microbiome bottleneck entirely, delivering the compound regardless of individual gut bacteria composition
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Longevity BoxTimeline Mitopure Urolithin A
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about this product.

The pure, clinically studied urolithin A that Timeline pioneered, delivered in daily softgels. Not the popular version. The original. The formulation that produced the published human clinical data on mitochondrial function, muscle strength, and cellular ageing. 500 mg of Mitopure per two softgel serving, the exact dose used in the peer reviewed studies. Certified by NSF, Informed Sport, and the Clean Label Project. Vegan, non GMO, and formulated by the researchers who discovered urolithin A's mechanism of action in the first place.

You have probably heard about urolithin A by now. It has become one of the most talked about compounds in longevity science because it does something no supplement had previously done in humans. It triggers mitophagy, the cellular process that identifies and recycles damaged mitochondria, replacing them with functional new ones. This matters because mitochondrial dysfunction is one of the most consistently identified drivers of ageing, muscle loss, fatigue, and metabolic decline. Fix the mitochondria and you address the root of dozens of downstream ageing symptoms simultaneously. And urolithin A is the first compound with human clinical data showing it can do exactly that.

The problem is that dozens of brands now sell urolithin A. Most of them source generic urolithin A synthesised by third party manufacturers with no clinical research behind their specific formulation. They reference the published trials as if the research on Mitopure applies to their product. It does not. The clinical data on urolithin A, the human trials on muscle strength, mitochondrial biomarkers, and cellular ageing, were conducted on Mitopure specifically. This is the version Amazentis (the Swiss biotech behind Timeline) developed after over a decade of research into the compound. This is the version tested in randomised controlled trials. This is the version the scientific literature refers to when it discusses urolithin A supplementation. Every other urolithin A product on the market is a downstream imitation of this original.

Timeline delivers Mitopure at 500 mg per two softgel serving, the exact daily dose used across their published human clinical studies. The trials demonstrated improved mitochondrial biomarkers, increased muscle strength and endurance, and reduced signs of cellular ageing at this dosage. Softgel format enables consistent daily use without powder mixing or flavour interference. Certified by NSF, Informed Sport (for elite athlete use under WADA testing), and the Clean Label Project (independent verification of purity and freedom from contaminants). Vegan. Non GMO. The most rigorously validated urolithin A available.

Mitopure Urolithin A 500 mg per two softgel serving. Additional excipients per full label. Vegan capsule. Non GMO. Free from major allergens.

how to take it

i.

Take two softgels daily with water. Best taken with a meal containing dietary fat to support absorption of the lipid soluble compound. Morning is ideal for alignment with cellular energy cycles. Consistent daily use is essential. Mitochondrial turnover is gradual and benefits compound over weeks and months of uninterrupted supplementation. Pair with regular exercise, particularly resistance training, as physical activity independently stimulates mitophagy and may amplify the mitochondrial renewal response. Store in a cool, dry place. Not recommended during pregnancy or breastfeeding. Consult your healthcare professional if taking medications or managing a medical condition.

ii.

The original urolithin A. The one the research was done on. The one every other urolithin A product on the market is trying to imitate. At the exact clinical dose, in the certified format, from the company that discovered how it works in the first place. Because when you take a supplement based on human clinical data, taking the version that was in the human clinical trials is not a preference. It is the point.

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Customer reflections

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QQVerified Buyer

The first adrenal support that made a quick difference.

4 days ago

Gentle on a sensitive stomach, and I feel like myself again. I had tried two other glandulars before this and neither sat right.

MRVerified Buyer

Steadier mornings within a fortnight.

1 week ago

I was sceptical about glandulars, but my mid-afternoon crash has genuinely eased. One capsule with breakfast and I forget about it.

ALVerified Buyer

Subtle, but real.

2 weeks ago

Not a stimulant, which is exactly what I wanted. It took about ten days, then I realised I wasn’t dreading the afternoon any more.

SKVerified Buyer

My clinician recommended it.

3 weeks ago

Bought after a blood panel flagged a flat cortisol curve. Easy to take, no jitters, and the sourcing is refreshingly transparent.

TPVerified Buyer

Recovery feels faster.

1 month ago

Training hard through a stressful stretch and this has helped me bounce back between sessions. Already on my second bottle.

DVVerified Buyer

Does what it says.

1 month ago

No frills, one ingredient, a sensible dose. I appreciate that it is designed to be used for a season rather than forever.

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