Free deliveryWhy The Wellness recommends this
Curated, not stocked.
ChromaDex is not a white-label operation — they are the originating scientists behind nicotinamide riboside as a supplement ingredient, and Tru Niagen is their own consumer brand. We recommend it because the provenance is clear, the human research on NR raising NAD+ is among the more robust in the longevity supplement space, and the dose here is clinically meaningful rather than token. For patients asking about NAD+ support, this is the reference product we point to.
About this product
Tru Niagen PRO 1000mg
Tru Niagen PRO 1000mg is a high-dose nicotinamide riboside (NR) supplement from ChromaDex, the company that pioneered and holds the foundational patents on NR as a consumer ingredient. Nicotinamide riboside is a form of vitamin B3 that serves as a direct precursor to NAD+, a coenzyme central to cellular energy metabolism, DNA repair, and mitochondrial function. NAD+ levels decline measurably with age, and NR is one of the more studied oral strategies for raising them.
This formulation is suited to those who have made an informed decision to support NAD+ levels at a meaningful dose — whether for general longevity interest, during periods of physiological stress, or alongside medical guidance for conditions where mitochondrial support is relevant. At this dose, it sits at the higher end of the NR range available without prescription.
ChromaDex supplies NR as NIAGEN to many other supplement brands, so sourcing it direct from ChromaDex means you are working with the originator of the ingredient. The science around NR continues to mature; human trials have consistently shown that oral NR raises whole-blood NAD+ levels, though the downstream health implications of this are still being studied. This is a supplement to sit alongside a sensible diet and lifestyle, not a replacement for understanding your baseline through blood testing.
What it does
Benefits
- 01
Raises NAD+ levels via a direct, well-studied B3 precursor
- 02
Supports mitochondrial energy production at the cellular level
- 03
Relevant for age-related decline in NAD+ availability
- 04
High-dose format for those seeking a meaningful NR intake
- 05
Sourced from the originator brand behind the NIAGEN ingredient
Get the most from it
How to use
Take 2 capsules daily, as directed on the packaging. Many users take NR in the morning with or without food, as it does not typically require food for absorption. Consistency over weeks is more relevant than timing.
What's inside
Ingredients
View full ingredient list
Nicotinamide Riboside 1000mg
Common questions
Frequently asked
How is nicotinamide riboside different from regular niacin or NMN?
Nicotinamide riboside (NR), niacin, and NMN are all NAD+ precursors but follow different biochemical pathways to get there. NR is generally better tolerated than niacin (which can cause flushing) and has a more established human trial record than NMN at this stage. They are not interchangeable, though they share the same end goal of raising NAD+.
How long before I notice a difference?
Human studies have shown measurable increases in blood NAD+ levels within two to four weeks of consistent NR supplementation. Subjective changes — if any — tend to be subtle; this is not a supplement with an immediate, noticeable effect for most people. Think of it as a long-term investment rather than a short-term fix.
Is it safe to take alongside other supplements or medications?
NR is generally considered well-tolerated, but if you are taking medications — particularly those affecting DNA repair pathways or cancer treatments — speak to your doctor before adding a high-dose NAD+ precursor. As with any supplement at this dose, a clinical conversation is worthwhile if you have an underlying condition.
Who is this not suitable for?
Pregnant or breastfeeding individuals should avoid NR supplements unless advised otherwise by a clinician, as safety data in these groups is limited. Those with a history of certain cancers should consult their oncologist, given that NAD+ plays a role in cell proliferation pathways.
Why is Tru Niagen more expensive than other NR supplements?
ChromaDex manufactures NIAGEN, the NR ingredient that many competing brands actually buy from them and repackage. Purchasing Tru Niagen PRO means you are buying directly from the source. The price also reflects the higher dose format — check the per-milligram cost against alternatives before assuming it is less competitive.
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